U.S. manufacturing growth cooling; bottlenecks starting to abate

Desy Papper
  • ISM manufacturing index decreases to 59.5 in July
  • New orders measure falls, employment gauge rises

WASHINGTON, Aug 2 (Reuters) – U.S. manufacturing activity grew at a slower pace in July for the second straight month as raw material shortages persisted, though there are signs of some easing in supply-chain bottlenecks.

The survey from the Institute for Supply Management (ISM) on Monday showed a measure of prices paid by manufactures fell by the most in 16 months, while the supplier deliveries index retreated further from a 47-year high touched in May.

Timothy Fiore, chair of ISM’s manufacturing business survey committee, noted

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Shaping the parts of the future

Desy Papper

CREAT3D helps shape LISI Aerospace’s additive manufacturing (AM) capabilities through applications engineering and advice. And by introducing the Markforged 3D printing technology, the team are able to test and validate too.

LISI Aerospace’s manufacturing plant in Rugby specialises in the manufacture of fasteners for the aircraft industry, providing fasteners for key clients including Airbus and the civil aircraft market. Key criteria for the manufacturing team are performance excellence, safety and innovation.

The manufacturing unit produces numerous variants of fasteners every day, split into three core departments: feeder (raw materials), manufacturing, plating testing and despatch. Having started with Ultimaker FFF printers,

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Catamaran Bio Announces Appointment of Joseph Gold, PhD, as Vice President, Technical Operations and Manufacturing

Desy Papper

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Catamaran Bio, Inc., a biotechnology company developing off-the-shelf CAR-NK cell therapies to treat cancer, today announced the appointment of Joseph Gold, PhD, as Vice President, Technical Operations and Manufacturing. Dr. Gold is a recognized leader with more than 25 years of experience in cell and gene therapy process development and GMP manufacturing. As head of Technical Operations and Manufacturing at Catamaran, he will lead the development of key aspects of the company’s TAILWIND™ Platform, including transposon-based NK cell engineering, process development and scale-up, as well as GMP manufacturing of Catamaran’s CAR-NK product candidates.

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Arcturus Therapeutics Collaborates with Vingroup to Establish Manufacturing Facility in Vietnam for Arcturus’ Investigational mRNA Vaccines for COVID-19

Desy Papper

SAN DIEGO–(BUSINESS WIRE)–Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a leading clinical-stage messenger RNA medicines company focused on the development of infectious disease vaccines and significant opportunities within liver and respiratory rare diseases, announced today an agreement with Vinbiocare Biotechnology Joint Stock Company (“Vinbiocare”), a member of Vingroup Joint Stock Company, regarding a collaboration to establish a manufacturing facility in Vietnam for the manufacture of Arcturus’ investigational COVID-19 vaccines, for sale and use within Vietnam.

Under the terms of the arrangement, Vinbiocare will, with consultation from Arcturus, build out a manufacturing facility in Vietnam, and Arcturus

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Phase-Dependent Approaches to Plasmid DNA Manufacture

Desy Papper

Plasmid DNA lies at the heart of viral and mRNA vector production because it provides the coding sequences for gene-based advanced therapy medicinal products (ATMPs). Its manufacture is therefore critical to both the supply and success of these products.

The manufacture of plasmid DNA is certainly critical if viral vectors are produced via transient transfection. This production route calls for the manufacture of up to four plasmids. Otherwise, production may not lead to an initial vector suitable for first-in-human studies.

Production routes that require multiple plasmids put additional pressure on plasmid manufacture, which also needs to supply enough plasmids to

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